2024 college football picks, Week 10 odds, lines, best bets from Vegas expert: This 3-leg parlay pays 6-1

In the biggest matchup on the Week 10 college football schedule, No. 4 Ohio State will visit No. 3 Penn State on Saturday for a contest with massive Big Ten championship and College Football Playoff implications. The Buckeyes are favored by 3.5 points on the road according to the latest Week 10 college football odds via the SportsLine consensus, with the over/under at 46.5. That’s one of only two ranked-versus-ranked matchups this week, with the other pitting No. 18 Pitt against No. 20 SMU in a big ACC matchup.

SMU is favored by 7.5 at home (O/U 57.5), according to the Week 10 college football lines. The Mustangs are 5-3 against the spread this season, while the Panthers are 6-1 ATS in 2024. So which Vegas college football spreads, money lines and totals are the furthest off and how can you use them to build a winning Week 10 college football parlay? Before locking in any Week 10 college football picks, be sure to see the top Week 10 college football expert picks, predictions and best bets from Thomas Casale.

A frequent guest on national radio and TV shows to discuss college sports, Casale has been sports betting — and winning — for more than 30 years. Over the past two college football seasons, Casale is 122-92-5 (57%) overall on his college football picks and 26-8 (76.4%) in bowl games — all publicly documented. Anybody who has followed him is way up.

Now, he has turned his attention to the Week 10 college football odds and is sharing his top three betting picks. If you parlay these college football betting picks, you could be looking at a return of around 6-1. Get his top college football picks at SportsLine.

Top Week 10 college football expert predictions

One of Casale’s top Week 10 college football picks: He is backing Iowa (-3) over Wisconsin on Saturday at 7:30 p.m. ET for the Heartland Trophy. This is a rivalry that dates back to 1894 with a 72-pound brass bull trophy that has been awarded to the winner since 2004. Wisconsin holds a 49-46-2 edge all-time but Iowa has won the last two head-to-head matchups.

This time around, Casale is expecting more of the same due, in part, to Iowa’s home-field advantage. The Hawkeyes are 4-1 at Kinnick Stadium this year with the only loss coming by a single point (20-19) against No. 11 Iowa State. Iowa held Northwestern to 43 rushing yards last week and should be able to make it Wisconsin one-dimensional.

“The Badgers simply don’t have a passing game to threaten defenses down the field, so it’s imperative they move the football on the ground,” Casale says. “That won’t be an easy task on Saturday. Iowa ranks 22nd at defending the run and allows just over 70 rushing yards per game at home.” See what other picks Casale likes at SportsLine. 

How to make Week 10 college football picks 

Casale has also found two other college football picks he loves, including a must-see pick where he is betting a huge underdog. You can only see his picks at SportsLine.

What are the best bets for Week 10 of college football, and which huge underdog should you be backing? Visit SportsLine now to see Thomas Casale’s college football best bets, all from a proven college football handicapper who has gone 26-8 on bowl games the past two seasons, and find out.